期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 331, 期 -, 页码 58-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.04.017
关键词
Inflammation; Circumventricular organs; Fever; NF-kappa B; Fos
资金
- Japan Society for the Promotion of Science [16K07027]
- NICHD
- Grants-in-Aid for Scientific Research [16K07027] Funding Source: KAKEN
Toll-like receptor 4 (TLR4) recognizes bacteria-derived lipopolysaccharide (LPS). In the present study, we found that intraperitoneal LPS activated nuclear factor-kappa B (NF-kappa B) in TLR4-expressing neural stem cells (NSCs) in the circumventricular brain regions of mice. Intracerebroventricular preadministration of low-dose TLR4 inhibitors significantly augmented hyperthermia together with the inhibition of NF-kappa B activation in circumventricular NSCs of LPS-inflamed animals. Moreover, intracerebroventricular administration of high-dose TLR4 inhibitors induced hyperthermia and Fos activation in circumventricular NSCs and hypothalamic neurons. These results suggest that TLR4 on circumventricular NSCs functions as a central regulator for thermogenesis under inflamed and normal conditions.
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