期刊
JOURNAL OF NEUROCHEMISTRY
卷 147, 期 5, 页码 584-594出版社
WILEY
DOI: 10.1111/jnc.14557
关键词
bipolar disorder; depression; migration; mood affective disorder; neural stem cell; stroke
资金
- MEXT KAKENHI [17H05512, 17H05750, 16H04671, 16K14578]
- JSPS KAKENHI [17H01392, 17K18007, JP16H06280, 26870282, 17K17215]
- Fugaku Trust for Medical Research
- Brain Science Project of the Center for Novel Science Initiatives (CNSI)
- National Institutes of Natural Sciences (NINS) [BS261007, BS281002]
- JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers [S2704]
- Grants-in-Aid for Scientific Research [16K14578, 17H01392, 17K17215, 17K18007, 16H04671, 26870282, 17H05750, 17H05512] Funding Source: KAKEN
In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity to differentiate into neurons and glia as demonstrated by in vitro studies. However, their contribution to tissue repair in disease and injury is limited, lending credence to the claim by prominent neuropathologist Ramon y Cajal that 'once development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably'. However, recent progress toward understanding the fundamental biology of adult NSCs and their role in pathological conditions has provided new insight into the potential therapeutic utility of endogenous NSCs. In this short review, we highlight two topics: the altered behavior of NSCs after brain damage and the dysfunction of NSCs and oligodendrocyte precursor cells, another type of undifferentiated cell in the adult brain, in mood affective disorders.
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