期刊
JOURNAL OF NEURAL TRANSMISSION
卷 125, 期 11, 页码 1651-1658出版社
SPRINGER WIEN
DOI: 10.1007/s00702-018-1887-z
关键词
MAO-B; Transgenic; Parkinson disease; Oxidative stress; Mitochondrial dysfunction; Neuroinflammation; Cellular senescence; Brain aging
Several studies have suggested that increases in astrocytic monoamine oxidase B (MAO-B) levels in conjunction with Parkinson's disease (PD) may contribute to subsequent neuropathology associated with the disorder. MAO-B inhibitors are currently widely used as symptomatic therapeutics for PD and, although somewhat controversial, these drugs may also exhibit disease-modifying properties. To obtain a better understanding of the potential role of MAO-B in disease neuropathology, we created an inducible astrocyte-specific transgenic MAO-B mouse model. Here, we summarize findings associated with this model, including neuropathological PD features associated with it.
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