期刊
JOURNAL OF NEURAL ENGINEERING
卷 15, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1741-2552/aa9dae
关键词
intracortical microelectrode arrays; molecular and cellular neurobiology; foreign body response; brain-computer interface; biocompatibility; biotic and abiotic failure
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS094900, R01NS094404, R01NS094396, R01NS062019, R01NS089688] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS094396, R01 NS094404, R21 NS094900, R01 NS089688, R01 NS062019] Funding Source: Medline
Objective. Implantable neural electrode devices are important tools for neuroscience research and have an increasing range of clinical applications. However, the intricacies of the biological response after implantation, and their ultimate impact on recording performance, remain challenging to elucidate. Establishing a relationship between the neurobiology and chronic recording performance is confounded by technical challenges related to traditional electrophysiological, material, and histological limitations. This can greatly impact the interpretations of results pertaining to device performance and tissue health surrounding the implant. Approach. In this work, electrophysiological activity and immunohistological analysis are compared after controlling for motion artifacts, quiescent neuronal activity, and material failure of devices in order to better understand the relationship between histology and electrophysiological outcomes. Results. Even after carefully accounting for these factors, the presence of viable neurons and lack of glial scarring does not convey single unit recording performance. Significance. To better understand the biological factors influencing neural activity, detailed cellular and molecular tissue responses were examined. Decreases in neural activity and blood oxygenation in the tissue surrounding the implant, shift in expression levels of vesicular transporter proteins and ion channels, axon and myelin injury, and interrupted blood flow in nearby capillaries can impact neural activity around implanted neural interfaces. Combined, these tissue changes highlight the need for more comprehensive, basic science research to elucidate the relationship between biology and chronic electrophysiology performance in order to advance neural technologies.
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