期刊
JOURNAL OF NERVOUS AND MENTAL DISEASE
卷 206, 期 5, 页码 356-361出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/NMD.0000000000000806
关键词
Attenuated psychosis; clinical high-risk for psychosis; prodromal psychosis; motor processes; dopamine
资金
- NIMH [K23MH106746, R01MH093398, R01NIMH107558]
- New York State Office of Mental Hygiene
- Allergan
- Otsuka
- Genentech
- BioAdvantex
The Structured Interview for Psychosis-Risk Syndromes (SIPS) contains criteria for the Attenuated Positive Symptom Syndrome (APSS), a period of subthreshold positive symptoms that predates full-blown psychosis. Motor abnormalities are often associated with these symptoms but have not been adequately studied. We assessed a diverse sample of 192 APSS participants (27.1% female; 47.9% white; mean age = 20.03 years) for motor dysfunction (SIPS G.3. score) at baseline and conversion to psychosis every 3 months for up to 2 years. Fifty-nine (30.7%) participants converted to psychosis. Baseline G.3. score was significantly higher among converters than nonconverters (mean difference = 0.66; t[95.929] = 2.579, p < 0.05). No significant differences in baseline G.3. were found between demographic groups or those with differential medication use. These results point to the use of G.3. as a potential predictor of psychosis among APSS individuals and potentially implicate the shared biological underpinnings of motor dysfunction in the APSS and full-blown psychotic illnesses.
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