期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 5, 页码 1295-1299出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00180
关键词
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资金
- JSPS KAKENHI Grants [25252037, 16H04980, 17H06403]
- JSPS [16J07837, 17J08775]
- Grants-in-Aid for Scientific Research [17J08775, 16J07837] Funding Source: KAKEN
Poecillastrin H (1), a chondropsin-type macrolide with a conjugated pentaene moiety, was isolated from the Characella sp. marine sponge. The planar structure of 1 was elucidated by analysis of spectroscopic data. The absolute configuration of the beta-hydroxyaspartic acid residue (beta-OHAsp) was determined to be D-threo by Marfey's analysis, and the mode of lactone ring formation through the OHAsp residue was determined by chemical degradation. Poecillastrin H was extremely sensitive toward light and showed potent cytotoxic activity against 3Y1 cells with an IC50 value of 4.1 nM.
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