期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 4, 页码 1108-1112出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00101
关键词
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资金
- JSPS KAKENHI [25252037, 16H04980, 17H06403]
- JSPS Research Fellowship for Young Researchers [16J07837]
Morphology-guided cell-based screening of the extract of a Mycale sp. marine sponge led to the isolation of two trisoxazole macrolides, miuramides A (1) and B (2), which induced characteristic morphological changes in 3Y1 cells. The structure of 1 including absolute configuration was elucidated by a combination of the analysis of spectroscopic data, derivatization, and degradation. Both compounds exhibit potent cytotoxicity against 3Y1 cells.
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