期刊
JOURNAL OF NATURAL PRODUCTS
卷 81, 期 4, 页码 1050-1054出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00644
关键词
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资金
- National Natural Science Foundation of China [21372208, 41676127]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Scientific and Technological Innovation Project [2015ASKJ02]
- Qingdao National Laboratory for Marine Science and Technology [2015ASTP-ES09]
- Shandong province key research and development program [2016GSF201204]
- Fundamental Research Funds for the Central Universities [201564026]
Two new depsipeptides (1 and 2), together with three known related compounds, pestalotin (3), pestalotiopyrone L (4), and PC-2 (5), were discovered in the extract of a mangrove derived fungus Sarocladium kiliense HDN11-112. The structures of saroclides A and B were established by interpretation of extensive NMR spectroscopic data and X-ray crystallographic analysis. Compound 1 was also produced by Simplicillium lamellicola HDN13-430. Compounds 1 and 2 were inactive against five cancer cell lines and four pathogenic microorganisms, while compound 1 showed a lipid-lowering effect.
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