期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 18, 期 10, 页码 6746-6755出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2018.15514
关键词
BNNT; Magnetite Nanoparticles; Magnetohyperthermia; Cancer Treatment
类别
资金
- FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais)
- CNPQ (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- CAPES (Comissao Aperfeicoamento de Pessoal de Nivel Superior)
Nanostructured materials have been widely studied aiming to biomedical applications, primarily for the purpose of carrying drugs or molecules of interest in a selected tissue or organ. In this context, boron nitride nanotubes (BNNTs), when functionalized with specific moieties, could be useful as nanovectors for delivery of proteins, drugs, and also RNAi molecules, due to their capacity to be uptaked by cells. The introduction of magnetic nanoparticles allows the use of such system as a hyperthermia agent. Thus, once it has been targeted to tumor areas, it could kill cancer cells by magnetohyperthermia therapy. In order to study this effect, magnetite nanoparticles were incorporated into hydroxilated BNNT. The system was characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and vibrating sample magnetometry (VSM). The results obtained show that magnetite nanoparticles are linked to the nanotubes. Magnetic measurements show that coercivity and magnetization were not disturbed after incorporation to the BNNT. Based on this, a new methodology for in vitro magnetohyperthermia experiments was developed, aiming to treat each cell group individually preserving its sterility. The biological assays of the system demonstrate its good cell viability and the great potential of this nanomaterial as a magnetohyperthermia agent for cancer treatment.
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