期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 18, 期 4, 页码 2330-2336出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2018.14391
关键词
Doxorubicin; Silica Nanoparticles; Colon Cancer; Chemotherapy
类别
资金
- Zhejiang Provincial Foundation for Health Department [2015KYA150]
- Wenzhou Municipal Science and Technology Project for Public Welfare [Y20140662]
- China Scholarship Council [201208330266]
- Natural Science Foundation of Zhejiang Province, PRC [Y4110029]
In the following study, we describe the preparation and characterization of poly(ethylene glycol) (PEG) and biotin modified, doxorubicin (DOX) loaded silica nanoparticles (Dox/SLN-PEG-Biotin), which was employed as a drug delivery system for colon cancer therapy. The DOX/SLN-PEG-Biotin exhibited small particle size and low cytotoxicity in vitro. Moreover, the Dox releases from DOX/SLN-PEG-Biotin followed a redox-sensitive behavior. Biotin functionalized Dox/SLN-PEG-Biotin demonstrated tumor-targeted delivery of their payload, resulting in enhanced cellular uptake in HCT116 tumor cells and potentiated tumor accumulation in HCT116 tumor-bearing mice. In particular, in vivo anti-cancer assay confirmed that DOX/SLN-PEG-Biotin as a tumor-targeted delivery system exerted strong anti-cancer efficacy. Altogether, DOX chemotherapy using DOX/SLN-PEG-Biotin might be an effective strategy for improved treatment in colon cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据