期刊
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
卷 39, 期 1-2, 页码 25-34出版社
SPRINGER
DOI: 10.1007/s10974-018-9495-y
关键词
BGP-15; Heat shock proteins; Skeletal muscle regeneration; Muscle contraction
类别
资金
- Sao Paulo Research Foundation (FAPESP) [14/23391-8]
- National Council for Scientific and Technological Development (CNPq) [305869/2015-9]
- FAPESP [13/04783-0]
- FAPESP/CAPES [14/13874-1]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/04783-0] Funding Source: FAPESP
This study investigated the effect of the heat shock protein inducer O-[3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime (BGP-15) on the morphology and contractile function of regenerating soleus muscles from mice. Cryolesioned soleus muscles from young mice treated daily with BGP-15 (15mg/Kg) were evaluated on post-cryolesion day 10. At this time point, there was a significant decrease in the cross-sectional area of regenerating myofibers, maximal force, specific tetanic force, and fatigue resistance of regenerating soleus muscles. BGP-15 did not reverse the decrease in myofiber cross-sectional area but effectively prevented the reduction in tetanic force and fatigue resistance of regenerating muscles. In addition, BGP-15 treatment increased the expression of embryonic myosin heavy chain (e-MyHC), MyHC-II and MyHC-I in regenerating muscles. Although BGP-15 did not alter voltage dependent anion-selective channel 2 (VDAC2) expression in cryolesioned muscles, it was able to increase inducible 70-kDaheat shock protein(HSP70) expression. Our results suggest that BGP-15 improves strength recovery in regenerating soleus muscles by accelerating the re-expression of adult MyHC-II and MyHC-I isoforms and HSP70 induction. The beneficial effects of BGP-15 on the contractile function of regenerating muscles reinforce the potential of this molecule to be used as a therapeutic agent.
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