期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1156, 期 -, 页码 564-570出版社
ELSEVIER
DOI: 10.1016/j.molstruc.2017.11.068
关键词
Monofunctional; Pd(II) dithiocarbamates; Anticancer; Hydrogen bonding; DNA binding; Antioxidant
资金
- TWAS (The World Academy of Sciences) project [11-143 RG/PHA/AS_C-UNESCO FR: 3240262658]
- Higher Education Commission, Pakistan
Two new heteroleptic Pd(II) complexes of sodium 4-(2-pyrimidyl)piperazine-1-carbodithioate with tris-p-flourophenylphosphine (1) and tris-p-chlorophenylphosphine (2) were prepared and characterized by elemental analysis, FT-IR, multinuclear NMR {H-1, C-13 and P-31} and single-crystal X-ray diffraction measurement. In both complexes, Pd exhibit pseudo square planner geometry mediated by SS chelate, P and Cl. In vitro cytotoxicity against five different cancer cell lines using staurosporine as a standard revealed 1 to be more cytotoxic than 2, though both complexes are more active than cisplatin. Subsequent DNA binding studies revealed that non-covalent complex-DNA interaction may be the reason for arresting cancer cell growth. Furthermore, 1 and 2 are potent antioxidant agents. (C) 2017 Elsevier B.V. All rights reserved.
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