期刊
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
卷 254, 期 2, 页码 243-252出版社
SPRINGER
DOI: 10.1007/s00417-015-3039-6
关键词
Hypoxia; Oximetry; Oxygen saturation; Retina; Retinitis pigmentosa
资金
- National Science & Technology Pillar Program of the Twelfth Five-Year Plan [2012BAI08B02]
This study was conducted to determine whether oxygen saturation and retinal blood vessel diameter are affected by retinitis pigmentosa (RP) at various ages. Relative oxygen saturation was measured in retinal blood vessels in 68 RP patients and 136 normal subjects using the Oxymap T1 retinal oximeter. Subjects were divided into two age groups: Group A (20-40 years) and Group B (> 40 years). One randomly selected eye of each subject was used for statistical analysis. Student's t tests were used to analyze the mean saturation and diameter of retinal arterioles and venules and arteriovenous differences between RP and normal subjects in the two age groups. A Spearman test was used to analyze the correlation of mean saturation of retinal arterioles (AS) and arteriovenous differences (AVS) with visual acuity, disease duration, and electroretinogram (ERG) b-wave amplitude in patients with RP. AS was significantly higher in patients with RP (105.5 +/- 9.4 %) than in normal subjects (94.5 +/- 4.4 %, p = 0.000) in Group A, while in Group B, AS was significantly lower in RP patients (86.8 +/- 10.3 %) than in healthy subjects (96.0 +/- 4.8 %, p = 0.000). Vessel diameter was smaller in RP patients than in normal subjects. AS and AVS showed a negative correlation with disease duration and a tendency toward positive correlation with ERG b-wave in patients with RP. The shifting characteristics of retinal vessel oxygen saturation suggest that the pathological mechanism of retinal oxygen metabolic disorder differs by age in patients with RP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据