期刊
EMERGING INFECTIOUS DISEASES
卷 20, 期 4, 页码 649-657出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2004.131718
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We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum beta-lactamase encoding gene bla(CTX-M), documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p<0.001). The prevalence of quinolone resistance encoding genes qnrB and qnrS increased from 6.6% and 8.2% before travel to 36.9% and 55.7% after travel, respectively (both p<0.001). Travel to Southeast Asia and the Indian subcontinent was associated with the highest acquisition rates of qnrS and both bla(CTX-M) and qnrS, respectively. Investigation of the associations between the acquisitions of the bla(CTX-M) and qnr genes showed that acquisition of a bla(CTX-M) gene was not associated with that of a qnrB (p = 0.305) or qnrS (p = 0.080) gene. These findings support the increasing evidence that travelers contribute to the spread of antimicrobial drug resistance.
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