期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 61, 期 2, 页码 T211-T231出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-17-0252
关键词
marine; sulfates; steroids; antitumor; antimicrobial
资金
- FCT/MCTES-Foundation for Science and Technology from the Minister of Science, Technology and Higher Education (PIDDAC)
- European Regional Development Fund (ERDF) through the COMPETE-Programa Operacional Factores de Competitividade (POFC) programme [PTDC/MAR-BIO/4694/2014, POCI-01-0145-FEDER-016790, 3599 PPCDT, PTDC/AAG-TEC/0739/2014, POCI-01-0145-FEDER-016793, 9471 RIDTI]
Marine environment is rich in structurally unique molecules and can be an inspiring source of novel drugs. Currently, six marine-derived drugs are in the market with FDA approval and several more are in the clinical pipeline. Structurally diverse and complex secondary metabolites have been isolated from the marine world and these include sulfated steroids. Biological activities of nearly 150 marine sulfated steroids reported from 1978 to 2017 are compiled and described, namely antimicrobial, antitumor, cardiovascular and antifouling activities. Structure-activity relationship for each activity is discussed.
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