期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 61, 期 1, 页码 T1-T10出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-17-0236
关键词
pregnancy-associated plasma protein-A; insulin-like growth factor; stanniocalcin breast cancer; ovarian cancer; lung cancer; mesothelioma; melanoma; Ewing sarcoma
资金
- NIA [AG28141]
- Mayo Clinic
- Danish Council for Independent Research
The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.
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