期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 430, 期 19, 页码 3585-3612出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.01.011
关键词
Cell polarity; Scribble module; Protein interactions; Cell signaling; Tumourigenesis
资金
- National Health and Medical Research Council Australia (NHMRC) [APP1103871]
- NHMRC Fellowship [APP1020056]
- Australian Research Council Fellowship [FT130101349]
- Juan de la Cierva-Incorporacion postdoctoral fellowship from the Spanish Ministerio de Ciencia e Innovacion (MICINN) [IJCI-2014-19272]
- Australian Government RTP Scholarship
- La Trobe University
- La Trobe Institute of Molecular Science
The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dig) and Lethal-2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The Scribble module proteins play key functions in the establishment and maintenance of different modes of cell polarity, as well as in the control of tissue growth, differentiation and directed cell migration, and therefore are major regulators of tissue development and homeostasis. Whilst molecular details are known regarding the roles of Scribble module proteins in cell polarity regulation, their precise mode of action in the regulation of other key cellular processes remains enigmatic. An accumulating body of evidence indicates that Scribble module proteins play scaffolding roles in the control of various signaling pathways, which are linked to the control of tissue growth, differentiation and cell migration. Multiple Scrib, Dig and Lgl interacting proteins have been discovered, which are involved in diverse processes, however many function in the regulation of cellular signaling. Herein, we review the components of the Scrib, Dig and Lgl protein interactomes, and focus on the mechanism by which they regulate cellular signaling pathways in metazoans, and how their disruption leads to cancer. (C) 2018 Elsevier Ltd. All rights reserved.
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