期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 430, 期 14, 页码 1965-1992出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.04.040
关键词
Virus; mTOR; protein synthesis; stress granules; ribosome profiling
资金
- University of Ottawa Graduate Scholarship
- Ontario Graduate Scholarship
- University of Ottawa Faculty of Medicine Destination 2020 Scholarship
- Canadian Breast Cancer Foundation/Canadian Cancer Society Research Institute
- Cancer Research Society/CIHR Institute of Cancer Research [22124]
- Natural Sciences and Engineering Research Council of Canada [RGPIW-2016-05228]
- Terry Fox Research Institute (New Frontier Program Project Grant)
In the early stages of infection, gaining control of the cellular protein synthesis machinery including its ribosomes is the ultimate combat objective for a virus. To successfully replicate, viruses unequivocally need to usurp and redeploy this machinery for translation of their own mRNA. In response, the host triggers global shutdown of translation while paradoxically allowing swift synthesis of antiviral proteins as a strategy to limit collateral damage. This fundamental conflict at the level of translational control defines the outcome of infection. As part of this special issue on molecular mechanisms of early virus host cell interactions, we review the current state of knowledge regarding translational control during viral infection with specific emphasis on protein kinase RNA-activated and mammalian target of rapamycin-mediated mechanisms. We also describe recent technological advances that will allow unprecedented insight into how viruses and host cells battle for ribosomes. (C) 2018 Elsevier Ltd. All rights reserved.
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