期刊
JOURNAL OF MEDICAL MICROBIOLOGY
卷 67, 期 8, 页码 1083-1089出版社
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000788
关键词
Klebsiella penumoniae; septic shock; pneumonia; liver abscess; acute respiratory distress syndrome; virulence
类别
Purpose. Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a leading cause of severe community-acquired pneumonia, liver abscess and disseminated infection in the Far East. Data regarding the incidence, clinical features and microbiological characteristics related to hvKp infections in the Western world are scarce. Methodology. The incidence, clinical features and microbiological characteristics of hvKp infections were investigated through a 5-year survey conducted in a single French intensive care unit. K. pneumoniae strains were screened for hypermucoviscosity based on a string test. Multilocus sequence typing and multiplex PCR analysis targeting virulence genes were performed on string test-positive strains. Results. Over a 53-month period, a total of 59 infections due to K. pneumoniae were identified including 26 community-onset infections. Twelve hvKp infections were documented, accounting for 46.1% of community-acquired K. pneumoniae. Community-acquired pneumonia (n= 6), aspiration pneumonia (n= 4) and liver abscess (n= 2) represented initial sites and mode of infection. Compared to non-hvKp infections, patients with hvKp infections displayed higher rates of multi-organ failure (83.3% vs 35.7 %; P= 0.04), but mortality rates were not different (50% vs 35 %; P= 0.71). Strains K1/ST23 (n= 5) and K2/ST86 (n= 5) predominated. All hvKp strains displayed wild-type susceptibility. Conclusion. hvKp represent a potentially underestimated cause of fatal infections in the Western world.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据