期刊
JOURNAL OF LUMINESCENCE
卷 199, 期 -, 页码 363-371出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jlumin.2018.03.071
关键词
Drug carrier; Long afterglow imaging; Magnetic resonance imaging; Porous nanoparticles
类别
资金
- Bureau of International Cooperation, Chinese Academy of Sciences [132C35KYSB20160021]
- National Natural Science Foundation of China [21507129, 61705228]
- Shuang Bai Plan of Fujian Province
- Program of International Cooperation of Xiamen [3502Z20161248]
Here, a kind of porous nanoparticles GdAlO3:Cr3+, Sm3+ (GAO:Cr,Sm) which own magnetic resonance and long persistent luminescent properties have been synthesized. The spherical morphology and narrow size distribution would allow the GAO:Cr, Sm nanoparticles to be utilised as a drug carrier and the drug release results indicate that the GAO:Cr, Sm drug carriers have an excellent drug sustained properties. Applying the Cr3+ and Sm3+ coped with gadolinium aluminate as the NIR persistent luminescence center and the energy transfer resonance from Gd3+ to Cr3+, these nanoparticles exhibit excellent NIR persistent luminescence at 732 nm under the UV irradiation of 254 nm and it can persist for about half an hour. In addition, they possess a longitudinal relaxivity (r(1)) value of 4.75 mM(-1) s(-1), which means that these nanoparticles could be applied for MR imaging as contrast agents. Carboxymethyl Chitosan was modified on the surface of GAO:Cr, Sm nanoparticles to make them owning excellent biocompatibility and low toxicity and these nanoparticles were successful to realize in vivo imaging. Hence, the well-defined nanoprobes of GAO:Cr, Sm exhibit great potential in biomedicine as trackable drug carriers and in vivo imaging agent due to the dual-model imaging property.
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