期刊
JOURNAL OF LIPID RESEARCH
卷 59, 期 9, 页码 1554-1560出版社
ELSEVIER
DOI: 10.1194/jlr.R083964
关键词
cell signaling; endocytosis; membranes; phospholipases; phospholipids; exosomes
资金
- Institut National du Cancer Grant [2013-105]
- Association pour la Recherche sur le Cancer Grant [PJA 20161204584]
- Fonds Wetenschappelijk Onderzoek Grants [G.0846.15, G0C5718N]
- Stichting Tegen Kanker Grant [2016-104]
- Ligue Contre le Cancer (France)
Extracellular vesicles released by viable cells (exosomes and microvesicles) have emerged as important organelles supporting cell-cell communication. Because of their potential therapeutic significance, important efforts are being made toward characterizing the contents of these vesicles and the mechanisms that govern their biogenesis. It has been recently demonstrated that the lipid modifying enzyme, phospholipase D (PLD)2, is involved in exosome production and acts downstream of the small GTPase, ARF6. This review aims to recapitulate our current knowledge of the role of PLD2 and its product, phosphatidic acid, in the biogenesis of exosomes and to propose hypotheses for further investigation of a possible central role of these molecules in the biology of these organelles.
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