期刊
GLIA
卷 63, 期 8, 页码 1376-1393出版社
WILEY
DOI: 10.1002/glia.22852
关键词
Schwann cell; peripheral nervous system; neural crest; Schwann cell precursor; immature Schwann cell; radial sorting; myelinating Schwann cell; Remak Schwann cell
资金
- National Institutes of Health [NS045630, HD075363, NS079445, NS083052]
- European Community FP7-EU
- Muscular Dystrophy Association
- Telethon Italy
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R21HD075363] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS079445, R01NS045630, R21NS083052] Funding Source: NIH RePORTER
In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact with axons throughout development. Schwann cells generate the insulating myelin sheath and provide vital trophic support to the neurons that they ensheathe. Schwann cell precursors arise from neural crest progenitor cells, and a highly ordered developmental sequence controls the progression of these cells to become mature myelinating or nonmyelinating Schwann cells. Here, we discuss both seminal discoveries and recent advances in our understanding of the molecular mechanisms that drive Schwann cell development and myelination with a focus on cell-cell and cell-matrix signaling events. GLIA 2015;63:1376-1393
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