期刊
CURRENT GERIATRICS REPORTS
卷 3, 期 2, 页码 91-100出版社
SPRINGER
DOI: 10.1007/s13670-014-0080-y
关键词
Olfaction; Alzheimer's disease; Mild cognitive impairment; Aging; Early detection; Amyloid plaque; Tau; Neurofibrillary tangle; Olfactory epithelium; Olfactory bulb; Piriformcortex; Orbitofrontal cortex; Entorhinal cortex; Hippocampus
资金
- National Institute ofMental Health [T32]
- Charles and Lee Brown Fellowship
- National Institute on Aging and Eli Lilly (investigator-initiated research grant)
Preclinical detection of Alzheimer's disease is critical to determining at-risk individuals in order to improve patient and caregiver planning for their futures, and to identify individuals likely to benefit from treatment as advances in therapeutics develop over time. Identification of olfactory dysfunction at the preclinical and early stages of the disease is a potentially useful method to accomplish these goals. We first review basic olfactory circuitry. We then evaluate the evidence of pathophysiological change in the olfactory processing pathways during aging and Alzheimer's disease in both human and animal models. We also review olfactory behavioral studies during these processes in both types of models. In doing so, we suggest hypotheses about the localization and mechanisms of olfactory dysfunction and identify important avenues for future work.
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