期刊
GLIA
卷 63, 期 6, 页码 921-935出版社
WILEY
DOI: 10.1002/glia.22795
关键词
enteric glia; enteric nervous system; astrocytes; neural crest; differentiation
资金
- National Institute for Translational Neuroscience (INNT) of the Ministry of Science and Technology
- Brazilian Federal Agency for the Support and Evaluation of Graduate Education (CAPES) of the Ministry of Education
- National Council for Technological and Scientific Development (CNPq)
- Rio de Janeiro State Research Foundation (FAPERJ)
- Ary Frauzino Foundation
- Federal University of Rio de Janeiro (UFRJ)
Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many characteristics with astrocytes, the main glial cell type of the central nervous system (CNS), such as in their expression of the same markers and in their functions. Here we review the construction of the enteric nervous system (ENS), with a focus on enteric glia, and also the main studies that have revealed the action of enteric glia in different aspects of gastrointestinal tract homeostasis, such as in the intestinal barrier, in communications with neurons, and in their action as progenitor cells. We also discuss recent discoveries about the roles of enteric glia in different disorders that affect the ENS, such as degenerative pathologies including Parkinson's and prion diseases, and in cases of intestinal diseases and injury. GLIA 2015;63:921-935
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据