期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 103, 期 5, 页码 829-838出版社
WILEY
DOI: 10.1002/JLB.3RI0917-361R
关键词
Cellular Heterogeneity; Immunity; Innate; Neutrophils
资金
- Canadian Institutes of Health Research (CIHR)
- Canada Research Chairs Program
- Heart and Stroke Foundation of Canada
- Alberta Innovates Health Solutions (AIHS)
Neutrophils are key components of the innate immune system that play important roles during infection, injury, and chronic disease. In recent years, neutrophil heterogeneity has become an emerging focus with accumulating evidence of neutrophil populations with distinct functions under both steady-state and pathologic conditions. Despite these advances, it remains unclear whether these different populations represent bona fide subsets or simply activation/polarization states in response to local cues. In this review, we summarize the varied neutrophils populations that have been described under both basal and during inflammation. We discuss the evidence that supports the existence of neutrophils subsets. Finally, we identify potential gaps in our knowledge that may further advance our current understanding of neutrophil heterogeneity. Review on neutrophil subsets in both healthy and diseased states.
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