期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 104, 期 4, 页码 777-786出版社
WILEY
DOI: 10.1002/JLB.3VMR0118-036R
关键词
90k; CyCAP; innate immunity; LGALS3BP; Mac-2-binding protein; SRCR
资金
- Academy of Finland [295296, 308613, 314119]
- Sigrid Juselius Foundation (Junior Group Leader grant)
- University of Turku, Finland
- Academy of Finland (AKA) [295296, 308613, 314119, 295296, 314119, 308613] Funding Source: Academy of Finland (AKA)
Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ongoing inflammation and microbial infection, such as IFN-alpha, IFN-beta, IFN-gamma, TNF-alpha, poly(I:C), dsRNA, and dsDNA. Furthermore, Gal-3BP belongs to the scavenger receptor cysteine-rich (SRCR) domain-containing protein family, by virtue of its N-terminal SRCR domain. The SRCR domain is found in soluble or membrane-associated innate immunity-related proteins and is implicated in self-nonself discrimination. This review summarizes the current knowledge of structural features of Gal-3BP and its proposed intracellular and extracellular innate immunity functions with special emphasis on viral and bacterial infections.
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