期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 104, 期 2, 页码 333-341出版社
WILEY
DOI: 10.1002/JLB.3MR0218-062R
关键词
chemokines; ectopic lymphoid structures; rheumatoid arthritis; synovium
资金
- MRC Grant [36661, MR/K015346/1]
- ARUK Grant [20022]
- MRC [MR/K015346/1] Funding Source: UKRI
Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft rejection, autoimmune conditions, and cancer. In this review, we will first depict the mechanisms regulating ELS generation, focusing on the role played by lymphoid chemokines. We will then characterize ELS forming in target organs during autoimmune conditions, here exemplified by rheumatoid arthritis, and cancer, highlighting the relevance of the tissue-specific factors. Finally, we will discuss the clinical significance of ELS and the therapeutic potential of their inhibition and/or enhancement depending on the disease considered.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据