期刊
JOURNAL OF PSYCHOTHERAPY INTEGRATION
卷 24, 期 2, 页码 109-121出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0036975
关键词
reward responsiveness; adolescent; substance abuse; depressive disorders
资金
- ANT North America Inc. (Advanced Neuro Technology)
- Astra-Zeneca
- Shire
- Servier
- Ono Pharma U.S.A.
- Andrew P. Merrill Research Fellowship award through Mclean Hospital
- Kaplen Fellowship on Depression award through Harvard Medical School
- NIMH [K23MH097786, R01MH68376, 1R01MH095809]
- Mclean Hospital
- NIDA [K24DA019855]
The goals of the present study were to examine: (a) putative dysfunctions in reward responsiveness in a sample of adolescents (n = 40) with co-occurring depressive and substance use disorders; (b) possible links between reward responsiveness and symptoms of depression, anhedonia, anxiety, and motivation for change in relation to alcohol and drug use; and (c) potential gender differences in findings. Before and after a 2-week residential treatment, adolescents completed self-report assessments of depression, anhedonia, anxiety symptoms, and motivation for change in relation to substance use. In addition, participants completed a computer-based Probabilistic Reward Task (PRT) to examine reward responsiveness (i.e., participants' ability to modulate behavior as a function of reinforcement history). Results indicated that depression and anhedonia symptoms decreased, and motivation for change in relation to drug use increased. Improved reward responsiveness over the course of residential treatment emerged in female, but not male, participants.
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