期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 180, 期 -, 页码 26-32出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.11.027
关键词
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Two triazolopyrimidine complexes have been obtained from reaction between 7-amino-1,2,4-triazolo[1,5-a] pyrimidine (7atp) and Cu (II) salts. Crystal structures of (Cu-2(mu-7atp)(4)Cl-2]Cl-2 center dot 4H(2)O(1) and [Cu-2(mu-7atp)(4)(H2O)(2)](NO3)(4)center dot H2O (2) have been studied by X-ray diffraction methods and characterized by spectroscopic and thermal analysis. Magnetic studies of these dinuclear complexes have revealed the existence of moderate antiferromagnetic interactions between the copper ions, with J values of - 91.2 and - 96.1 cm(-1) respectively. It must be highlighted that the antiparasitic activity of these new complexes has been studied in vitro against three different strains of leishmania spp. and Trypanosoma cruzi, showing a higher efficacy than the 7atp ligand and the reference commercial drugs.
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