期刊
JOURNAL OF INFECTIOUS DISEASES
卷 217, 期 10, 页码 1553-1560出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy072
关键词
Malaria; breath; volatile organic compounds; terpenes; biomarkers
资金
- National Institutes of Health [R01AI103280, R21AI123808-01]
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital
- Burroughs Wellcome Fund
- Washington University Monsanto Excellence Fund
Current evidence suggests that malarial infection could alter metabolites in the breath of patients, a phenomenon that could be exploited to create a breath-based diagnostic test. However, no study has explored this in a clinical setting. To investigate whether natural human malarial infection leads to a characteristic breath profile, we performed a field study in Malawi. Breath volatiles from children with and those without uncomplicated falciparum malaria were analyzed by thermal desorption-gas chromatography/mass spectrometry. Using an unbiased, correlation-based analysis, we found that children with malaria have a distinct shift in overall breath composition. Highly accurate classification of infection status was achieved with a suite of 6 compounds. In addition, we found that infection correlates with significantly higher breath levels of 2 mosquito-attractant terpenes, alpha-pinene and 3-carene. These findings attest to the viability of breath analysis for malaria diagnosis, identify candidate biomarkers, and identify plausible chemical mediators for increased mosquito attraction to patients infected with malaria parasites.
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