期刊
JOURNAL OF INFECTIOUS DISEASES
卷 218, 期 6, 页码 892-900出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy262
关键词
EBV; KSHV; saliva; shedding; Uganda
资金
- Intramural Program of the National Cancer Institute, National Institutes of Health, Department of Health and Human Services [HHSN261200800001E]
- Wellcome Trust [064693, 079110, 95778, 090132]
- UK Medical Research Council (MRC)
- UK Department for International Development (DfID), under the MRC/DfID concordat
- MRC [MC_UP_1204/15, MC_UU_00027/5] Funding Source: UKRI
Background. Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are transmitted via saliva, but factors associated with salivary shedding are unknown. Methods. We measured the DNA load of both viruses in saliva specimens collected from approximately 500 Ugandan mothers and their 6-year-old children, testing all participants for EBV and KSHV-seropositive individuals for KSHV. Results. EBV and KSHV were shed by 72% and 22% of mothers, respectively, and by 85% and 40% of children, respectively; boys were more likely than girls to shed KSHV (48% vs 30%) but were equally likely to shed EBV. Children shed more KSHV and EBV than mothers, but salivary loads of EBV and KSHV were similar. KSHV shedding increased with increasing anti-KSHV (K8.1) antibodies in mothers and with decreasing antimalarial antibodies both in mothers and children. Among mothers, 40% of KSHV shedders also shed EBV, compared with 75% of KSHV nonshedders; among children, EBV was shed by 65% and 83%, respectively. Conclusions. In summary, in this population, individuals were more likely to shed EBV than KSHV in saliva. We identified several factors, including child's sex, that influence KSHV shedding, and we detected an inverse relationship between EBV and KSHV shedding, suggesting a direct or indirect interaction between the two viruses.
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