期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 67, 期 -, 页码 365-372出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2018.07.009
关键词
Endothelial growth factor (EGF); Basic fibroblast growth factor (bFGF); Glycol chitosan (GCH); Visible light curing; Wound healing
资金
- Technology Innovation Program - Ministry of Trade, Industry, and Energy (MOTIE, Republic of Korea) [10053595]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) [2014R1A1A1002697, 2017R1D1A1B03033195, 2017R1D1A1B03030497, 2016R1A2B4014600]
Wounds that heal with excessive scar formation result in poor functional and aesthetic outcomes. To address this, in our study, visible light cured glycol chitosan (GCH) hydrogels containing endothelial growth factor (EGF) and basic fibroblast growth factor (bFGF) were prepared (GCH-EGF, GCH-FGF and GCH-EGF/FGF) and evaluated their efficacies on the improvement of wound healing in vivo. In vitro release test showed that the growth factors were released in a sustained manner along with initial burst for 24 h. In vitro cell proliferation assay of L-929 mouse fibroblast cell line resulted in the superior ability of GCH-EGF/FGF on the rate. In vivo results demonstrated that the growth factor loaded GCHs further enhanced wound healing compared with GCH. In particular, GCH-EGF/EFG showed the most remarkable wound healing effect among the samples. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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