期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 59, 期 -, 页码 251-258出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2017.10.030
关键词
Dissolving microneedle; Mechanical property; Humidity
资金
- National Natural Science Foundation of China [51473017, 51673019]
- Fundamental Research Funds for the Central Universities [buctrc201406]
- Innovation and Promotion Project of Beijing University of Chemical Technology
- Ministry of Finance of PRC
- Ministry of Education of PRC
Dissolving microneedles (DMNs) prepared from soluble polymers has been being widely investigated as a safe and effective transdermal delivery system for drug and vaccine. Limited by the materials, the air humidity would probably affect the mechanical property of DMNs, which is essential for the effective needle insertions and drug delivery. In this study, four kinds DMNs prepared by polyvinyl alcohol, sodium hyaluronate (HA), chitosan and gelatin are studied on the mechanical strength and insertion ability under varying humidity conditions. Based on these investigations, we hope to provide the effective time of DMNs to ensure a successful insertion and drug delivery. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据