期刊
JOURNAL OF IMMUNOLOGY
卷 200, 期 7, 页码 2439-2454出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1701117
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- Italian Ministry of University and Research Fondo per gli Investimenti della Ricerca di Base Grant [RBAP11H2R9]
- Italian Association for Cancer Research
- Italian Ministry of Health
- National Research Council of Italy EPIGEN flagship project
The enzymes of the poly-ADP-ribose polymerase (PARP) superfamily control many relevant cellular processes, but a precise understanding of their activities in different physiological or disease contexts is largely incomplete. We found that transcription of several Parp genes was dynamically regulated upon murine macrophage activation by endotoxin. PARP14 was strongly induced by several inflammatory stimuli and translocated into the nucleus of stimulated cells. Quantitative mass spectrometry analysis showed that PARP14 bound to a group of IFN-stimulated gene (ISG)-encoded proteins, most with an unknown function, and it was required for their nuclear accumulation. Moreover, PARP14 depletion attenuated transcription of primary antiviral response genes regulated by the IFN regulatory transcription factor 3, including Ifnb1, thus reducing IFN-beta production and activation of ISGs involved in the secondary antiviral response. In agreement with the above-mentioned data, PARP14 hindered Salmonella typhimurium proliferation in murine macrophages. Overall, these data hint at a role of PARP14 in the control of antimicrobial responses and specifically in nuclear activities of a subgroup of ISG-encoded proteins.
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