期刊
JOURNAL OF HOSPITAL INFECTION
卷 100, 期 4, 页码 463-468出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2018.03.034
关键词
Respiratory syncytial virus; Adults; Viral pneumonia; Influenza
Background: Information on the role of respiratory syncytial virus (RSV) in adult patients with influenza-like syndrome is scarce. Aim: To assess the clinical characteristics of RSV in adult patients with respiratory manifestations during a regular influenza season. Methods: Prospective study in a tertiary Spanish hospital from December 2015 to February 2016. The study population included only adult patients with either community-acquired or hospital/healthcare-associated influenza-like illness, according to the European Centre for Disease Prevention and Control criteria. Samples were analysed using a rapid molecular assay (Xpert (R) Flu/RSV). RSV-positive patients were compared with a randomly negative control group and with an influenza-positive control group. Findings: Twelve hundred patients with influenza-like respiratory infection were included. Overall, 114 of the samples (9%) were positive for influenza and 95 (8%) were positive for RSV. When RSV-positive and influenza-positive patients were compared, RSV-positive patients were older (57.7 vs 48.9 years; P = 0.03), and their disease was more frequently healthcare-related (26/95, 27.3% vs 5/114, 1.7%; P < 0.001). They also had significantly more antibiotics prescribed (77/95, 81.0% vs 70/114, 61.4%; P < 0.001) and more frequently needed hospital admission (93/95, 97.8% vs 69/114, 60.5%; P < 0.001). Mortality was also significantly higher in RSV-positive patients (14/95, 14.7% vs 7/114, 6.1%; P = 0.04). Conclusion: RSV is a major cause of moderate-to-severe respiratory infection during the influenza season; acquisition is frequently nosocomial or healthcare-related; and mortality is significantly higher than with influenza virus infection. The use of a rapid molecular test as a first-step diagnostic technique is necessary to ensure that isolation measures are implemented and that spread is prevented. (C) 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据