期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 66, 期 4, 页码 321-336出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/0022155417740881
关键词
extracellular matrix; glycosaminoglycans; heparan sulfate; heparin; inflammation; innate immunity
类别
资金
- Australian Research Council [LP140101056]
- Australian Research Council [LP140101056] Funding Source: Australian Research Council
Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.
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