期刊
JOURNAL OF HETEROCYCLIC CHEMISTRY
卷 55, 期 8, 页码 1854-1862出版社
WILEY
DOI: 10.1002/jhet.3234
关键词
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资金
- Zhejiang Provincial Natural Science Foundation [LQ16B050002]
- Research Project of Zhejiang Provincial Department of Education [Y201533271]
Hybridization, a strategy based on the covalent fusion of two or more existing pharmacophores to create a single molecule with multiple mechanisms of action, represents an encourage approach in the development of new drugs with potential therapeutic application in several pathologies. Triazoles and quinolones occupy an important position in medicinal chemistry attribute to their various biological activities, so hybridization of these two pharmacophores may provide more effective candidates that might be able to prevent the drug resistance. This review outlines the biological activities of triazole-quinolone hybrids, and discusses their structure-activity relationship.
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