4.2 Article

ON SIMILARITIES IN INFRARED SPECTRA OF COMPLEX DRUGS

期刊

ROMANIAN REPORTS IN PHYSICS
卷 66, 期 2, 页码 382-393

出版社

EDITURA ACAD ROMANE

关键词

Chromatographic separation; Combivir; Epivir; Kaletra; Norvir; Prezista; Retrovir; Trivizir; Valcyte; Viramune; visualization

资金

  1. Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [Gr/34/11]

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A chromatographic separation of active ingredients of Combivir, Epivir, Kaletra, Norvir, Prezista, Retrovir, Trivizir, Valcyte, and Viramune is performed on thin layer chromatography. The spectra of these nine drugs were recorded using the Fourier transform infrared spectroscopy. This information is then analyzed by means of the cosine correlation. The comparison of the infrared spectra in the perspective of the adopted similarity measure is possible to visualize with present day computer tools, and the emerging clusters provide additional information about the similarities of the investigated set of complex drugs.

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