期刊
EMERGING INFECTIOUS DISEASES
卷 20, 期 7, 页码 1176-1182出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2007.131265
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资金
- Division of Global Emerging Infections Surveillance and Response System Operations at the Armed Forces Health Surveillance Center through USAMRIID [C0169_10_RD, C0410_11_RD, C0602_12_RD]
- US Department of Defense Cooperative Biological Engagement Program through Metabiota, Inc., San Francisco, CA, USA
Sierra Leone in West Africa is in a Lassa fever hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of approximate to 500-700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in eastern Sierra Leone. Generally only 30%-40% of samples tested are positive for Lassa virus (LASV) antigen and/or LASV-specific IgM; thus, 60%-70% of these patients have acute diseases of unknown origin. To investigate what other arthropod-borne and hemorrhagic fever viral diseases might cause serious illness in this region and mimic Lassa fever, we tested patient serum samples that were negative for malaria parasites and LASV. Using IgM-capture ELISAs, we evaluated samples for antibodies to arthropod-borne and other hemorrhagic fever viruses. Approximately 25% of LASV-negative patients had IgM to dengue, West Nile, yellow fever, Rift Valley fever, chikungunya, Ebola, and Marburg viruses but not to Crimean-Congo hemorrhagic fever virus.
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