期刊
PHYSIOLOGICAL REPORTS
卷 2, 期 7, 页码 -出版社
WILEY
DOI: 10.14814/phy2.12083
关键词
AAV technology; arcuate nucleus; GWAS; Negr1; ventromedial hypothalamus
类别
资金
- European Community's Seventh Framework Programme (FP7) [245009, 266408]
Neural growth regulator 1 (Negr1) is among the first common variants that have been associated with the regulation of body mass index. Using AAV technology directed to manipulate Negr1 expression in vivo, we find that decreased expression of Negr1 in periventricular hypothalamic areas leads to increases in body weight, presumably via increased food intake. Moreover, we observed that both increased and decreased levels of Negr1 lead to reduced locomotor activity and body temperature. In sum, our results provide further support for a role of hypothalamic expressed Negr1 in the regulation of energy balance.
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