Antitumor Activity of Tetra-Substituted Zinc Phthalocyanines Containing 4(3H)-Quinazolinone Derivatives

Series of tetra-substituted zinc(II)phthalocyanines (ZnPcs) bearing four 4(3H) quinazolinone ring system units (qz)(4)ZnPcs 4a-c have been synthesized and characterized. They were screened for their in-vitro antitumor activity on Human lung adenocarcinoma (A549), human breast adenocarcinoma (MCF-7) and Hepatocellular carcinoma (HEPG2). Preliminary study of the structure-activity relationship showed that electronic factors in the 4(3H)-quinazolinone moiety that attached to the ZnPc skeleton had a magnificent effect on the antitumor activity of the newly synthesized (qz)(4)ZnPcs 4a-c. They showed promising anticancer activity against the tested human cancer cell lines. The detailed synthesis, characterization and biological screening data were reported.