期刊
JOURNAL OF GASTROENTEROLOGY
卷 53, 期 4, 页码 475-483出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00535-018-1440-8
关键词
IgG4; Autoimmune pancreatitis; Regulatory T-cells; Regulatory B-cells; M2 macrophage; Basophil
资金
- JSPS KAKENHI [17K09468, 15K09052]
- Ministry of Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [17K09468, 15K09052] Funding Source: KAKEN
In 1995, Yoshida and colleagues proposed the concept of autoimmune pancreatitis (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancreatic manifestation of IgG4-related disease (IgG4-RD); and type 2, which is characterized by granulocytic epithelial lesions. Type 2 AIP is thought to be rare in Japan. Type 1 AIP is characterized by increased serum IgG4 concentrations, lymphoplasmacytic infiltrations, storiform fibrosis, and obliterative phlebitis. However, although type 1 AIP has become increasingly recognized, many clinical and basic issues remain to be solved. This review provides an overview of the recent clinical and basic knowledge of type 1 AIP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据