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F. Ann Ran et al.
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Eun-Joo Shin et al.
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Chia-Hsiung Chen et al.
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Hong Lian et al.
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S Kaul et al.
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P Storz et al.
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R Bright et al.
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AG Kanthasamy et al.
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LB Yang et al.
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I Vancurova et al.
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