期刊
CHINESE JOURNAL OF NATURAL MEDICINES
卷 12, 期 6, 页码 477-480出版社
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(14)60074-1
关键词
Illicium henryi; Sesquiterpene lactones; Anti-HBV activity
资金
- National Natural Science Foundation of China [81172961]
- External Cooperation Program of the Chinese Academy of Sciences [P2009- KF10]
AIM: To study the chemical constituents of the fruits of Illicium henryi. METHOD: Chromatographic separations on silica gel, Sephadex LH-20 gel and MCI gel were used to isolate the compounds. The structures were elucidated based on extensive spectroscopic data analyses. RESULTS: Seven compounds were obtained and their structures were identified as 10-benzoyl-cycloparvifloralone (1), cycloparvifloralone (2), 2 alpha-hydroxycycloparviforalone (3), henrylactone B (4), merrillianone (5), henrylactone C (6) and 7, 14-ortholactone-3-hydroxyfloridanolide (7). CONCLUSION: Compound 1 is a new sesquiterpene lactone. The tested compounds showed weak anti-HBV activities on HBV surface antigen (HBsAg) secretion and HBV e antigen (HBeAg) secretion using Hep G2.2.15 cell line.
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