Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle

The voltammetric behavior of doxorubicin at a ZnO nanoparticle/1-butyl-3-methylimidazolium tetrafluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) has been investigated. For the goal, ZnO-NPs were biosynthesized by celery extract in aqueous solution. The ZnO-NPs/BMTFB/CPE exhibits a good promoting effect on the oxidation response of doxorubicin. After optimization of pH condition, ZnO-NPs/BMTFB/CPE exhibits two separated oxidation signals for simultaneous analysis of doxorubicin and dasatinib with Delta E similar to 300 mV. The oxidation currents showed linear relation with doxorubicin or dasatinib concentration in the ranges of 0.07-500 mu M and 1.0-4200 mu M, respectively. We detected limit of detection 9.0 nM and 0.5 mu M for doxorubicin and dasatinib, respectively. The ZnO-NPs/BMTFB/CPE has been applied to the analysis of doxorubicin and dasatinib in injection and pharmaceutical serum samples.