期刊
STATA JOURNAL
卷 14, 期 2, 页码 363-380出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1536867X1401400208
关键词
st0341; steppedwedge; stepped wedge; sample size; cluster-randomized controlled trials; power; detectable difference
资金
- National Institute of Health Research
- Engineering and Physical Sciences Research Council Multidisciplinary Assessment of Technology Centre for Healthcare program [GR/S29874/01]
This article introduces the Stata menu-driven program steppedwedge, which calculates detectable differences and power for stepped-wedge randomized trials. The command permits continuous, binary, and rate outcomes (with normal approximations) for comparisons using two-sided tests. The command allows specification of the number of clusters randomized at each step, the number of steps and the average cluster (cell) size, or an incomplete design in which the user specifies the design pattern (a matrix with one row per cluster, one column per time point, and entries indicating exposure and observable data). Cluster heterogeneity can be parameterized using either the intracluster correlation or the coefficient of variation (of the outcome). The command is illustrated via examples.
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