Synthesis of perovskite-type SrTiO3 nanoparticles for sensitive electrochemical biosensing applications

In this work, SrTiO3 nanoparticles (SrTiO(3)NPs), a novel and effective perovskite-type material, are synthesized to modify electrode for the development of sensitive enzymatic electrochemical biosensor applications. The electrochemical behavior of glucose oxidase (GOx) immobilized on SrTiO(3)NPs-modified glassy carbon electrode is investigated. Scanning electron microscopy and cyclic voltammetry are used to characterize the morphology and assay property of different modified electrodes. Results illustrate that SrTiO(3)NPs possess large surface area and apparently enhance the direct electron transfer between GOx and modified electrode. The SrTiO(3)NPs-based enzyme biosensor shows a high sensitivity of 15.6 mA.(-1).cm(-2), wide linear range from 0.01 mM to 1.2 mM, and a low detection limit of 3 mu m (S/N = 3). Furthermore, the resultant glucose biosensor has excellent selectivity, acceptable repeatability, practicality and stability. The perovskite SrTiO(3)NPs provide a very attractive and potential electrode material to develop electrochemical biosensors.