4.3 Article

Transmission disequilibrium of rs4809957 in type 2 diabetes mellitus families and its association with vitamin D deficiency: A family-based case-control study

期刊

JOURNAL OF DIABETES AND ITS COMPLICATIONS
卷 32, 期 4, 页码 406-410

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2018.01.004

关键词

Type 2 diabetes mellitus; Vitamin D; CYP24A1; rs4809957; Family-based association test

资金

  1. Natural Science Foundation of China [81573151, 81573243, 81703270]
  2. Science and Technology Foundation for Innovation Talent of Henan Province [154200510010]
  3. National Key Research and Development Program Precision Medicine Initiative of China [2016YFC0900803]

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Aims: Association between T2DM and vitamin D was found in many epidemiologic reports. And 24-hydroxylase encoded by CYP24A1 is the very enzyme that degrades the active vitamin D metabolite. We aimed to investigate the association between rs4809957 in CYP24A1 and T2DM, as well as vitamin D level. Methods: A total of 419 pedigrees containing 1556 participants were included. T2DM diagnosis, 25(OH)D measurement and genotyping of rs4809957 were conducted for all the individual. Then association between rs4809957 and T2DM, as well as 25(OH)D level, was investigated by family-based association test (FBAT) and 1:1 matched case-control study. Results: The FBAT results revealed that there was transmission disequilibrium for allele G in T2DM families by both additive model (Z = 2.183, P = 0.029049) and recessive model (Z = 2.236, P = 0.025347). Allele G was also associated with 25(OH)D level in both additive model (Z = 2.549, P = 0.010811) and dominant model (Z = 2.012, P = 0.044187). On the other hand, results of case-control study suggested that vitamin D deficiency was a risk factor for T2DM (OR 1.987; 95%CI 1.331-2.964; P = 0.001). Further stratified analysis revealed that vitamin D deficiency increased T2DM risk in women (OR 2.347; 95%CI 1.373-4.012; P = 0.002), instead of men (OR 1.600; 95%CI 0.874-2.931; P = 0.127). In addition, T2DM patients with GG and AG genotypes were more susceptible to vitamin D deficiency than the control (P = 0.006 and P = 0.038, respectively). Conclusion: There was transmission disequilibrium for allele G of rs4809957 in T2DM families, which was linked to vitamin D deficiency. (C) 2018 Elsevier Inc. All rights reserved.

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