期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 90, 期 3, 页码 323-331出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2018.03.001
关键词
ALA; PpIX; EDTA-2Na; Pseudomonas aeruginosa; PDT; wound healing; infected wound
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology in Japan ([JSPS] KAKENHI Grant) [26462762, 25861726]
- Japan Agency for Medical Research and Development (AMED) [17K11584]
Background: Pseudomonas aeruginosa (PA) frequently develops antibiotic-resistant characteristics, which is clinically problematic. The main reason behind the rise of antibiotic-resistant PA is the extensive use of antibiotics. Therefore, a novel technique is needed to treat PA infections. Photodynamic therapy (PDT) is thought to have the potential to be a non-antibiotic treatment for infections. 5-Aminolevulinic acid (ALA), which works as a photosensitizer after being metabolized into protoporphyrin IX (PpIX) in the heme synthetic pathway, is used for PDT. Thus far, the in vivo effectiveness of PDT using ALA against PA is unknown. Objective: In this study, we investigated PDT using ALA both in vitro and in vivo. Methods and results: Although PDT with ALA alone did not show a bactericidal effect on PA, PDT with both ALA and EDTA-2Na had a bactericidal effect in vitro. In in vivo experiments, wounds healed faster in PA-infected mice treated with PDT using both EDTA-2Na and ALA compared to non-PDT. Conclusion: These results suggest that PDT with EDTA-2Na and ALA is a potential novel treatment option for PA-infected wounds. (C) 2018 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据