期刊
JOURNAL OF DENTAL RESEARCH
卷 97, 期 9, 页码 977-986出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034518778033
关键词
osseointegration; bone; dental implants; bone matrix; biocompatible materials; bone-implant interface
资金
- Swedish Research Council [K2015-52X-09495-28-4]
- ALF/LUA Research Grant [ALFGBG-448851]
- IngaBritt and Arne Lundberg Foundation
- Wilhelm and Martina Lundgren Foundation
- Dr. Felix Neubergh Foundation
- Promobilia
- Hjalmar Svensson Foundation
- Osteology Foundation
- Materials Science Area of Advance at Chalmers
- Department of Biomaterials, University of Gothenburg
In lamellar bone, a network of highly oriented interconnected osteocytes is organized in concentric layers. Through their cellular processes contained within canaliculi, osteocytes are highly mechanosensitive and locally modulate bone remodeling. We review the recent developments demonstrating the significance of the osteocyte lacuno-canalicular network in bone maintenance around implant biomaterials. Drilling during implant site preparation triggers osteocyte apoptosis, the magnitude of which correlates with drilling speed and heat generation, resulting in extensive remodeling and delayed healing. In peri-implant bone, osteocytes physically communicate with implant surfaces via canaliculi and are responsive to mechanical loading, leading to changes in osteocyte numbers and morphology. Certain implant design features allow peri-implant osteocytes to retain a less aged phenotype, despite highly advanced extracellular matrix maturation. Physicochemical properties of anodically oxidized surfaces stimulate bone formation and remodeling by regulating the expression of RANKL (receptor activator of nuclear factor-B ligand), RANK, and OPG (osteoprotegerin) from implant-adherent cells. Modulation of certain osteocyte-related molecular signaling mechanisms (e.g., sclerostin blockade) may enhance the biomechanical anchorage of implants. Evaluation of the peri-implant osteocyte lacuno-canalicular network should therefore be a necessary component in future investigations of osseointegration to more completely characterize the biological response to materials for load-bearing applications in dentistry and orthopedics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据